N-FORMYL-N-METHYLHYDRAZINE

Modify Date: 2025-08-26 17:28:54

N-FORMYL-N-METHYLHYDRAZINE Structure
N-FORMYL-N-METHYLHYDRAZINE structure
 Common Name N-FORMYL-N-METHYLHYDRAZINE
CAS Number 758-17-8 Molecular Weight 74.08180
Density 1.061g/cm3 Boiling Point 118.6ºC at 760 mmHg
Molecular Formula C2H6N2O Melting Point 219-222 °C
MSDS N/A Flash Point 25.5ºC

 Names

Name N-amino-N-methylformamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.061g/cm3
Boiling Point 118.6ºC at 760 mmHg
Melting Point 219-222 °C
Molecular Formula C2H6N2O
Molecular Weight 74.08180
Flash Point 25.5ºC
Exact Mass 74.04800
PSA 46.33000
LogP 0.28450
Index of Refraction 1.45
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ8940000
CHEMICAL NAME :
Formic acid, methylhydrazide
CAS REGISTRY NUMBER :
758-17-8
LAST UPDATED :
199612
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C2-H6-N2-O
MOLECULAR WEIGHT :
74.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 mg/kg/62W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
6100 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7840 mg/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3360 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3158 mg/kg/94W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3920 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
64 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84 mg/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
187 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
158 mg/kg/79W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 umol/plate
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 26,155,1983

 Safety Information

Hazard Codes T+

 Synthetic Route

monomethylhydrazine structure

monomethylhydrazine

CAS#:60-34-4

Ethyl formate structure

Ethyl formate

CAS#:109-94-4

~76%

N-FORMYL-N-METHYLHYDRAZINE Structure

N-FORMYL-N-METH...

CAS#:758-17-8

N'-methyl-N-formylhydrazine structure

N'-methyl-N-for...

CAS#:155106-68-6

Literature: Delalu, Henri; Sabate, Carlos Miro Chemistry - An Asian Journal, 2012 , vol. 7, # 4 p. 715 - 724
Formic Acid structure

Formic Acid

CAS#:64-18-6

monomethylhydrazine structure

monomethylhydrazine

CAS#:60-34-4

~90%

N-FORMYL-N-METHYLHYDRAZINE Structure

N-FORMYL-N-METH...

CAS#:758-17-8

Literature: Werner, Wolfgang; Depreux, Patrick Journal of Chemical Research, Miniprint, 1980 , # 11 p. 4513 - 4521
Ethoxymethaniminium chloride structure

Ethoxymethanimi...

CAS#:16694-46-5

monomethylhydrazine structure

monomethylhydrazine

CAS#:60-34-4

~%

N-FORMYL-N-METHYLHYDRAZINE Structure

N-FORMYL-N-METH...

CAS#:758-17-8

Literature: Kohn,H.; Olofson,R.A. Journal of Organic Chemistry, 1972 , vol. 37, # 22 p. 3504 - 3509
monomethylhydrazine structure

monomethylhydrazine

CAS#:60-34-4

Ethyl formate structure

Ethyl formate

CAS#:109-94-4

~%

N-FORMYL-N-METHYLHYDRAZINE Structure

N-FORMYL-N-METH...

CAS#:758-17-8

Literature: Pedersen,C.T. Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 2199 - 2200
methyl formate structure

methyl formate

CAS#:107-31-3

monomethylhydrazine structure

monomethylhydrazine

CAS#:60-34-4

~%

N-FORMYL-N-METHYLHYDRAZINE Structure

N-FORMYL-N-METH...

CAS#:758-17-8

Literature: Dorn,H. et al. Chemische Berichte, 1965 , vol. 98, p. 3377 - 3384 Show Details Zinner,G.; Gebhardt,U. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1971 , vol. 304, p. 706 - 712

 Synonyms

Hydrazine,1-formyl-1-methyl
N-METHYL-N-FORMYLHYDRAZINE
1-Methyl-1-formylhydrazide
Methylformylhydrazine
2-Methyl-2-formylhydrazine
1-Formyl-1-methylhydrazin
Formic acid,methylhydrazide
N-amino-N-methyl-formamide
Formic acid,1-methylhydrazide
N-methylformic hydrazide
N-formyl-N-methylhydrazine
1-formyl-1-methylhydrazine
1-methyl-1-formyl-hydrazine
1-Methylformylhydrazine
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