Chk2 Inhibitor
Modify Date: 2025-08-25 17:05:36
Chk2 Inhibitor structure
|
Common Name | Chk2 Inhibitor | ||
|---|---|---|---|---|
| CAS Number | 724708-21-8 | Molecular Weight | 295.29600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Chk2 InhibitorChk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1]. |
| Name | indoloazepine |
|---|
| Description | Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1]. |
|---|---|
| Related Catalog | |
| Target |
Chk2:13.5 nM (IC50) Chk1:220.4 nM (IC50) |
| References |
| Molecular Formula | C15H13N5O2 |
|---|---|
| Molecular Weight | 295.29600 |
| Exact Mass | 295.10700 |
| PSA | 112.37000 |
| LogP | 1.25050 |