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Chk2 Inhibitor

Names

[ CAS No. ]:
724708-21-8

[ Name ]:
Chk2 Inhibitor

Biological Activity

[Description]:

Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)

[Target]

Chk2:13.5 nM (IC50)

Chk1:220.4 nM (IC50)


[References]

[1]. Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7(1):172-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H13N5O2

[ Molecular Weight ]:
295.29600

[ Exact Mass ]:
295.10700

[ PSA ]:
112.37000

[ LogP ]:
1.25050

Related Compounds