β-Casomorphin, bovine

Modify Date: 2024-01-03 12:48:19

β-Casomorphin, bovine structure	Common Name	β-Casomorphin, bovine
	CAS Number	72122-62-4	Molecular Weight	789.91700
	Density	1.32g/cm3	Boiling Point	1170.5ºC at 760 mmHg
	Molecular Formula	C₄₁H₅₅N₇O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	661.7ºC

Use of β-Casomorphin, bovine

β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

Name	β-CASOMORPHIN (BOVINE)
Synonym	More Synonyms

Description	β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Peptides
Target	IC50: 14 μM (Opioid receptor)[1]
In Vitro	β-casomorphin(β-casomorphin-7) strongly stimulates mucin secretion in the rat jejunum through a nervous pathway and opioid receptor activation. In rat DHE cells, β-casomorphin(β-casomorphin-7) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC. In human HT29-MTX cells, β-casomorphin(β-casomorphin-7) also increases MUC5AC mRNA levels (219% after 24 h of stimulation) and the secretion of this mucin. β-casomorphin(β-casomorphin-7) may contribute significantly to mucin production via a direct effect on intestinal goblet cells and the activation of -opioid receptors[2].
In Vivo	Oral administration of β-casomorphin(β-casomorphin-7) for 30 days to rats with STZ-induced diabetes results in a significant increase in serum level of insulin, and a decrease in the level of glucagon. The administration of β-casomorphin(β-casomorphin-7) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-casomorphin(β-casomorphin-7) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].
Cell Assay	After 24 h of serum starvation, rat DHE cells are incubated without (control) or with β-casomorphin(β-casomorphin-7) (1-100 μM) for 30 min to 24 h. The amount of mucinlike glycoprotein in culture media is measured by enzymelinked lectin assay (ELLA) using biotinylated wheat germ agglutinin[2].
Animal Admin	Rats[3] Diabetes is induced by intraperitoneal injection of STZ dissolved in 0.1 mol/L sodium citrate buffer (pH=4.0) at a dose of 60 mg/kg body weight. Fasting, tail-vein, blood glucose is measured three days after injection by using one touch glucomter, and Male Sprague-Dawley (SD) rats (200 g±10 g) that have a glucose level over 16.7 mM are considered to be diabetic rats. To investigate the preventive effects of β-casomorphin(β-casomorphin-7) treatment, β-casomorphin(β-casomorphin-7) treatment are carried out 2 weeks after the injection of STZ. All rats are euthanized after 30 days of treatment. On day 30, the animals are fasted overnight. Blood glucose, body and kidney weights are measured. Serum, plasma and kidney are collected for future analyses. All samples are stored at −70°C[3].
References	[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.

Density	1.32g/cm3
Boiling Point	1170.5ºC at 760 mmHg
Molecular Formula	C₄₁H₅₅N₇O₉
Molecular Weight	789.91700
Flash Point	661.7ºC
Exact Mass	789.40600
PSA	231.78000
LogP	2.38090
Index of Refraction	1.607
Storage condition	2-8℃

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β-Casomorphin, bovine

GL Biochem (Shanghai) Ltd.
China
Product Name: YPFPGPI
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Nanjing Peptide Biotech Ltd
China
Product Name: β-Casomorphin (bovine)
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Zhejiang Hangyu API Co., Ltd
China
Product Name: β-Casomorphin (bovine)
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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