74135-04-9

74135-04-9 structure

Name: β-Casomorphin (1-4) amide (bovine) acetate salt
Chemical Name: Tyr-Pro-Phe-Pro-NH2
CAS Number: 74135-04-9
Molecular Formula: C₂₈H₃₅N₅O₅
Molecular Weight: 521.60800
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-04-11 21:15:49
Modify Date: 2024-01-08 17:14:52
Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors[1].

Name	Tyr-Pro-Phe-Pro-NH2
Synonyms	Morphiceptin, Beta-Casomorphin (1-4) amide (bovine) B-CASOMORPHIN (1-4) AMIDE (BOVINE) cis-Morphiceptin Beta-Casomorphin (1-4) amide (bovine).Morphiceptin trans-Morphiceptin morphicetin morphiceptin N-((R)-α-methylbenzyl)-3-aminopropan-1-ol

Description	Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Morphine (μ) Receptor[1]
In Vivo	Morphiceptin potently inhibits the binding of [3H]dihydromorphine, 125I-labeled FK33824, and [3H]naloxone to rat brain membrane preparations with a 50 percent inhibition concentration (IC50) of about 20 nM[1].
References	[1]. Chang KJ, et al. Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors. Science. 1981;212(4490):75-77.