β-Casomorphin (human)

Modify Date: 2024-01-02 17:39:33

β-Casomorphin (human) structure	Common Name	β-Casomorphin (human)
	CAS Number	102029-74-3	Molecular Weight	863.99500
	Density	1.299 g/cm3	Boiling Point	1239.2ºC at 760 mmHg
	Molecular Formula	C₄₄H₆₁N₇O₁₁	Melting Point	N/A
	MSDS	USA	Flash Point	703.2ºC

Use of β-Casomorphin (human)

β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.

Name	β-Casomorphin
Synonym	More Synonyms

Description	β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease Peptides
Target	Opioid receptor[2]
In Vitro	β-Casomorphin, human (TyrPro-Phe-Val-Glu-Pro-Ile) is also called human B-casein-(51-57), with the sequenceequivalent to bovine B-casein-(60-66) (Tyr-ProPhe-Pro-G]y-Pro-Ile or B-casomorphin-7)[1]. β-Casomorphin, human (100 μM) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC in rat DHE cells, also elevates increased MUC5AC mRNA levels[2].
Cell Assay	To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].
References	[1]. Brantl V. Novel opioid peptides derived from human beta-casein: human beta-casomorphins. Eur J Pharmacol. 1984 Oct 30;106(1):213-4. [2]. Zoghbi S, et al. beta-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a mu-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.

Density	1.299 g/cm3
Boiling Point	1239.2ºC at 760 mmHg
Molecular Formula	C₄₄H₆₁N₇O₁₁
Molecular Weight	863.99500
Flash Point	703.2ºC
Exact Mass	863.44300
PSA	277.87000
LogP	3.21710
Storage condition	2-8℃

β-Casomorphin (human) MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

2-[[1-[2-[[2-[[2-[[1-[2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid

β-Casomorphin (1-7), human

β-Casomorphin, human