Spermine

Modify Date: 2025-08-20 18:04:58

Spermine Structure
Spermine structure
 Common Name Spermine
CAS Number 71-44-3 Molecular Weight 202.340
Density 0.9±0.1 g/cm3 Boiling Point 308.4±0.0 °C at 760 mmHg
Molecular Formula C10H26N4 Melting Point 310-311 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 175.6±22.6 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Spermine


Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.

 Names

Name spermine
Synonym More Synonyms

 Spermine Biological Activity

Description Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1].
References

[1]. Ha HC, et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 308.4±0.0 °C at 760 mmHg
Melting Point 310-311 °C (dec.)(lit.)
Molecular Formula C10H26N4
Molecular Weight 202.340
Flash Point 175.6±22.6 °C
Exact Mass 202.215744
PSA 76.10000
LogP -0.96
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.485
Storage condition 2-8°C
Water Solubility H2O: 1 M at 20 °C, clear, colorless

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ7175000
CHEMICAL NAME :
1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
CAS REGISTRY NUMBER :
71-44-3
BEILSTEIN REFERENCE NO. :
1750791
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H26-N4
MOLECULAR WEIGHT :
202.40
WISWESSER LINE NOTATION :
Z3M4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
2 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C: Corrosive;Xi: Irritant;
Risk Phrases R34
Safety Phrases S26-S36-S45-S36/37/39
RIDADR UN 3259 8/PG 2
WGK Germany 3
RTECS EJ7230000
Packaging Group III
Hazard Class 8
HS Code 2929909090

 Synthetic Route

 Customs

HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles155

More Articles
H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.

J. Endocrinol. 223(3) , 241-53, (2014)

The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing num...

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.

Breast Cancer Res. 17 , 19, (2015)

Targeted therapies for aggressive breast cancers like triple negative breast cancer (TNBC) are needed. The use of small interfering RNAs (siRNAs) to disable expression of survival genes provides a too...

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015)

The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a ...

 Synonyms

Spermin
1,4-Butanediamine, N,N-bis(3-aminopropyl)-
MUSCULAMINE HYDROCHLORIDE
EINECS 200-754-2
N,N'-Bis(3-aminopropyl)butane-1,4-diamine
N,N'-Bis(3-aminopropyl)-1,4-butanediamine
N,N'-Bis(3-aminopropyl)butan-1,4-diamin
N,N'-Bis(3-aminopropyl)-1,4-diaminobutane
N,N'-Bis(3-aminopropyl)tetramethylenediamine
Spermine
SPERMINE HYDROCHLORIDE
MFCD00012914
1,5,10,14-Tetraazatetradecane
NEURIDINE HYDROCHLORIDE
N1,N4-bis(3-aminopropyl)-1,4-butanediamine
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Spermine suppliers

Price: ￥550/10 mM * 1 mL in DMSO

Reference only. check more Spermine price

Related Compounds: More...
Spermine
9015-13-8
Aba-spermine
133009-20-8
Anb-spermine
138109-67-8
Boc2-spermine
140652-55-7
Spermine(HBBB)
114459-62-0
tri-Z-spermine
172992-25-5
Spermine(N3BBB)
1190203-80-5
Spermine Guanide
69358-08-3
Spermine NONOate
136587-13-8
3-(4-chlorophenyl)-1-[(2-chlorophenyl)methyl]-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
1326860-07-4
2-(4-fluorophenyl)-5-[(3-methylphenyl)methyl]-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one
1326834-34-7
5-[(4-tert-butylphenyl)methyl]-2-(4-fluorophenyl)-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one
1326926-93-5
5-[(3-fluoro-4-methoxyphenyl)methyl]-2-(4-fluorophenyl)-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one
1326907-52-1
1-benzyl-3-(4-ethoxyphenyl)-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
1326851-96-0
3-(4-ethoxyphenyl)-1-[(2-methylphenyl)methyl]-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
1326900-71-3
1-[(4-tert-butylphenyl)methyl]-3-(4-ethoxyphenyl)-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
1326890-16-7
3-{[3-(4-ethoxyphenyl)-2,4-dioxo-1H,2H,3H,4H-thieno[3,2-d]pyrimidin-1-yl]methyl}benzonitrile
1326908-40-0
1-[(3,5-difluorophenyl)methyl]-3-(4-ethoxyphenyl)-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
1326870-58-9
11-(4-Butoxyphenyl)-4-(2-phenylethyl)-3,4,6,9,10-pentaazatricyclo[7.3.0.0^{2,6}]dodeca-1(12),2,7,10-tetraen-5-one
1326890-76-9
Chemsrc provides Spermine(CAS#:71-44-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Spermine are included as well.>> amp version: Spermine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved