Spermine

Modify Date: 2024-01-02 11:56:22

Spermine structure	Common Name	Spermine
	CAS Number	71-44-3	Molecular Weight	202.340
	Density	0.9±0.1 g/cm3	Boiling Point	308.4±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₂₆N₄	Melting Point	310-311 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	175.6±22.6 °C
	Symbol	GHS05	Signal Word	Danger

Use of Spermine

Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.

Name	spermine
Synonym	More Synonyms

Description	Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1].
References	[1]. Ha HC, et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5.

Density	0.9±0.1 g/cm3
Boiling Point	308.4±0.0 °C at 760 mmHg
Melting Point	310-311 °C (dec.)(lit.)
Molecular Formula	C₁₀H₂₆N₄
Molecular Weight	202.340
Flash Point	175.6±22.6 °C
Exact Mass	202.215744
PSA	76.10000
LogP	-0.96
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.485
Storage condition	2-8°C
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

Spermine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7175000

CHEMICAL NAME :: 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-

CAS REGISTRY NUMBER :: 71-44-3

BEILSTEIN REFERENCE NO. :: 1750791

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H26-N4

MOLECULAR WEIGHT :: 202.40

WISWESSER LINE NOTATION :: Z3M4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 2 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C: Corrosive;Xi: Irritant;
Risk Phrases	R34
Safety Phrases	S26-S36-S45-S36/37/39
RIDADR	UN 3259 8/PG 2
WGK Germany	3
RTECS	EJ7230000
Packaging Group	III
Hazard Class	8
HS Code	2929909090

Precursor 7
CAS#:14209-32-6 N,N'-DICYANOETH... CAS#:78707-11-6 1,2-bis(1-tosyl... CAS#:78706-92-0 2-[2-(1,4,5,6-t... CAS#:12651-38-6 (+/-)-verbaskine
CAS#:124-20-9 spermidine CAS#:110-60-1 putrescine CAS#:73397-39-4 1-(4-aminobutyl...
DownStream 10
CAS#:306-67-2 spermine tetrah... CAS#:123-75-1 Pyrrolidine CAS#:120-94-5 1-Methylpyrrolidine CAS#:7664-41-7 Ammonia
CAS#:25593-72-0 N-acetylspermine CAS#:124-20-9 spermidine CAS#:109-76-2 1,3-Diaminopropane CAS#:123-38-6 Propionaldehyde
CAS#:136587-13-8 Spermine NONOate CAS#:352-92-1 3-aminopropanal

HS Code	2921290000
Summary	2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Spermin

1,4-Butanediamine, N,N-bis(3-aminopropyl)-

MUSCULAMINE HYDROCHLORIDE

EINECS 200-754-2

N,N'-Bis(3-aminopropyl)butane-1,4-diamine

N,N'-Bis(3-aminopropyl)-1,4-butanediamine

N,N'-Bis(3-aminopropyl)butan-1,4-diamin

N,N'-Bis(3-aminopropyl)-1,4-diaminobutane

N,N'-Bis(3-aminopropyl)tetramethylenediamine

Spermine

SPERMINE HYDROCHLORIDE

MFCD00012914

1,5,10,14-Tetraazatetradecane

NEURIDINE HYDROCHLORIDE

N1,N4-bis(3-aminopropyl)-1,4-butanediamine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Spermine
Price: ￥878.0/5g ￥358.0/1g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Spermine free base
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Spermine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Spermine suppliers

Price: ￥550/10 mM * 1 mL in DMSO

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Spermine

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