8α-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
Modify Date: 2024-01-06 18:05:51
8α-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate structure
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Common Name | 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate | ||
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| CAS Number | 67667-71-4 | Molecular Weight | 406.42600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H26O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1]. |
| Name | (4S,6R,7S,10R,E)-3-(acetoxymethyl)-7-hydroxy-6,10-dimethyl-2-oxo-2,4,5,6,7,8,9,10-octahydro-7,10-epoxycyclodeca[b]furan-4-yl methacrylate |
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| Description | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 8.64 μM (CYP2A6, pre-incubation), 22.3 μM (CYP2A6, co-incubation), 38.6 μM (MAO-B), 60.2 μM(MAO-A)[1] Ki: 15.1 μM (CYP2A6), 27.2 μM (MAO-B), 60.2 μM (MAO-A)[1] |
| References |
| Molecular Formula | C21H26O8 |
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| Molecular Weight | 406.42600 |
| Exact Mass | 406.16300 |
| PSA | 108.36000 |
| LogP | 2.07220 |
| Hazard Codes | Xi |
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