67667-71-4

67667-71-4 structure

Name: 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
Chemical Name: (4S,6R,7S,10R,E)-3-(acetoxymethyl)-7-hydroxy-6,10-dimethyl-2-oxo-2,4,5,6,7,8,9,10-octahydro-7,10-epoxycyclodeca[b]furan-4-yl methacrylate
CAS Number: 67667-71-4
Molecular Formula: C₂₁H₂₆O₈
Molecular Weight: 406.42600
Catalog: Natural product Sesquiter
Create Date: 2017-06-30 10:58:50
Modify Date: 2024-01-06 18:05:51
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].

Name	(4S,6R,7S,10R,E)-3-(acetoxymethyl)-7-hydroxy-6,10-dimethyl-2-oxo-2,4,5,6,7,8,9,10-octahydro-7,10-epoxycyclodeca[b]furan-4-yl methacrylate

Description	8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Inflammation/Immunology
Target	IC50: 8.64 μM (CYP2A6, pre-incubation), 22.3 μM (CYP2A6, co-incubation), 38.6 μM (MAO-B), 60.2 μM(MAO-A)[1] Ki: 15.1 μM (CYP2A6), 27.2 μM (MAO-B), 60.2 μM (MAO-A)[1]
References	[1]. Prasopthum A, et al. Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. Drug Metab Pharmacokinet. 2015 Apr;30(2):174-81.

Hazard Codes	Xi