Indirubin-3′-oxime
Modify Date: 2025-08-27 19:16:37
Indirubin-3′-oxime structure
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Common Name | Indirubin-3′-oxime | ||
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| CAS Number | 667463-82-3 | Molecular Weight | 277.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H11N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Indirubin-3′-oximeIndirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3]. |
| Name | Indirubin-3′-oxime |
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| Synonym | More Synonyms |
| Description | Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3]. |
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| Related Catalog | |
| Target |
GSK-3β JNK1:0.8 μM (IC50) JNK2:1.4 μM (IC50) JNK3:1 μM (IC50) CDK |
| In Vitro | In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner[1]. Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression[2]. |
| In Vivo | Indirubin-3′-oxime (0.05 or 0.5 mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters[3]. Animal Model: Three-week-old C57BL/6 mice[3] Dosage: 0.05 or 0.5 mg/kg Administration: I.p.; daily for 2 or 10 weeks Result: The tibial length of mice increased in a dose-dependent manner. |
| References |
| Molecular Formula | C16H11N3O2 |
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| Molecular Weight | 277.28 |
| Storage condition | 2-8°C |
| Hazard Codes | Xn |
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| MFCD02683594 |