Coleon-U-quinone
Modify Date: 2024-01-11 11:11:07
Coleon-U-quinone structure
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Common Name | Coleon-U-quinone | ||
|---|---|---|---|---|
| CAS Number | 65714-83-2 | Molecular Weight | 344.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Coleon-U-quinoneColeon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1]. |
| Name | Coleon-U-quinone |
|---|
| Description | Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1]. |
|---|---|
| Related Catalog | |
| Target |
P-glycoprotein[1] |
| In Vitro | Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1]. Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1]. Cell Viability Assay[1] Cell Line: NCI-H460, NCI-H460/R and MRC-5 Concentration: 0-50 μM Incubation Time: 72 h Result: Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM. Cell Proliferation Assay[1] Cell Line: NCI-H460/R Concentration: 1, 2 and 5 μM Incubation Time: 72 h Result: Sensitized NCI-H460/R cells to Doxorubicin (HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively. |
| References |
| Molecular Formula | C20H24O5 |
|---|---|
| Molecular Weight | 344.40 |