Coleon-U-quinone

Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1].

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

P-glycoprotein[1]

Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1]. Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1]. Cell Viability Assay[1] Cell Line: NCI-H460, NCI-H460/R and MRC-5 Concentration: 0-50 μM Incubation Time: 72 h Result: Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM. Cell Proliferation Assay[1] Cell Line: NCI-H460/R Concentration: 1, 2 and 5 μM Incubation Time: 72 h Result: Sensitized NCI-H460/R cells to Doxorubicin (HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.

[1]. Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680.