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65714-83-2

65714-83-2 structure

65714-83-2 structure

Name: Coleon-U-quinone
Chemical Name: Coleon-U-quinone
CAS Number: 65714-83-2
Molecular Formula: C₂₀H₂₄O₅
Molecular Weight: 344.40
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P-glycoprotein
Create Date: 2022-10-08 12:11:32
Modify Date: 2024-01-11 11:11:07
Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1].

Name	Coleon-U-quinone

Description	Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Target	P-glycoprotein[1]
In Vitro	Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1]. Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1]. Cell Viability Assay[1] Cell Line: NCI-H460, NCI-H460/R and MRC-5 Concentration: 0-50 μM Incubation Time: 72 h Result: Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM. Cell Proliferation Assay[1] Cell Line: NCI-H460/R Concentration: 1, 2 and 5 μM Incubation Time: 72 h Result: Sensitized NCI-H460/R cells to Doxorubicin (HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.
References	[1]. Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680.

Molecular Formula	C₂₀H₂₄O₅
Molecular Weight	344.40

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