8α,9α-Epoxycoleon-U-quinone
Modify Date: 2025-08-25 09:05:59
8α,9α-Epoxycoleon-U-quinone structure
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Common Name | 8α,9α-Epoxycoleon-U-quinone | ||
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| CAS Number | 93800-59-0 | Molecular Weight | 360.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 8α,9α-Epoxycoleon-U-quinone8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX[1]. |
| Name | 8α,9α-Epoxycoleon-U-quinone |
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| Description | 8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX[1]. |
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| Related Catalog | |
| In Vitro | 8α,9α-Epoxycoleon-U-quinone (2, 5, 10, 20, 50 μM; 72 h) selective towards cancer cell lines, with a selectivity index of 2.0[1]. 8α,9α-Epoxycoleon-U-quinone (10 μM; 72 h) is able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells[1]. 8α,9α-Epoxycoleon-U-quinone (1, 2, 5 μM; 72 h) reverses the resistance of cancer cells to DOX and increase anti-cancer efficacy of DOX[1]. Cell Viability Assay[1] Cell Line: NCI-H460, NCI-H460/R, MRC-5 cells Concentration: 2, 5, 10, 20, 50 μM Incubation Time: 72 h Result: Showed inhibition of cancer cell viability (IC50≈20 μM) with a selectivity index of 2.0. Cell Viability Assay[1] Cell Line: NCI-H460/R cells Concentration: 10 μM Incubation Time: 72 h Result: Decreased the Rho123 accumulation in NCI-H460/R cells, and no influence on the ABCB1 expression. Cell Viability Assay[1] Cell Line: NCI-H460/R cells Concentration: 1, 2, 5 μM (combine with Doxorubicin (DOX)) Incubation Time: 72 h (pre-treat) Result: Promoted sensitization of NCI-H4l60/R cells to DOX with relative reversal indexes of 1.976 and 4.696 for concentration of 1 and 2 μM, respectively. |
| References |
| Molecular Formula | C20H24O6 |
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| Molecular Weight | 360.40 |