metformin

metformin Structure
metformin
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Common Name metformin
CAS Number 657-24-9 Molecular Weight 129.164
Density 1.3±0.1 g/cm3 Boiling Point 172.5±23.0 °C at 760 mmHg
Molecular Formula C4H11N5 Melting Point N/A
MSDSmetformin MSDS|SDS|pdf download N/A Flash Point 58.1±22.6 °C

 Names

[ Name ]: metformin
[ Synonym ]: More Synonyms

 Chemical & Physical Properties

[ Density ]: 1.3±0.1 g/cm3
[ Boiling Point ]: 172.5±23.0 °C at 760 mmHg
[ Molecular Formula ]: C4H11N5
[ Molecular Weight ]: 129.164
[ Flash Point ]: 58.1±22.6 °C
[ Exact Mass ]: 129.101440
[ PSA ]: 88.99000
[ LogP ]: -2.31
[ Vapour Pressure ]: 1.3±0.3 mmHg at 25°C
[ Index of Refraction ]: 1.576

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU1790000
CHEMICAL NAME :
Biguanide, 1,1-dimethyl-
CAS REGISTRY NUMBER :
657-24-9
LAST UPDATED :
199601
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H11-N5
MOLECULAR WEIGHT :
129.20
WISWESSER LINE NOTATION :
MUYZMYUM&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
146 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 1-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
2 gm/L/48H
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

 Synthetic Route

Metformin hydrochloride结构式

CAS#:1115-70-4

Metformin hydro...

~10%

metformin Structure

CAS#:657-24-9

metformin

Literature: Veisi, Hojat; Khazaei, Ardeshir; Safaei, Maryam; Kordestani, Davood Journal of Molecular Catalysis A: Chemical, 2014 , vol. 382, p. 106 - 113
metformin hydrochloride结构式

CAS#:1378856-94-0

metformin hydro...

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metformin Structure

CAS#:657-24-9

metformin

Literature: Journal of Molecular Structure, , vol. 996, # 1-3 p. 38 - 41
N/A结构式

CAS#:1170667-82-9

N/A

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metformin Structure

CAS#:657-24-9

metformin

Literature: WO2010/100337 A1, ; Page/Page column 9 ;
N/A结构式

CAS#:1170667-83-0

N/A

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metformin Structure

CAS#:657-24-9

metformin

Literature: WO2010/100337 A1, ; Page/Page column 9-10 ;
N/A结构式

CAS#:127099-85-8

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metformin Structure

CAS#:657-24-9

metformin

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Dimethylamine hydrochloride结构式

CAS#:506-59-2

Dimethylamine h...

N/A结构式

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N/A

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metformin Structure

CAS#:657-24-9

metformin

Literature: Chemische Berichte, , vol. 62, p. 1394 Journal of the Chemical Society, , vol. 121, p. 1793
Dimethylamine结构式

CAS#:124-40-3

Dimethylamine

N/A结构式

CAS#:127099-85-8

N/A

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metformin Structure

CAS#:657-24-9

metformin

Literature: Chemische Berichte, , vol. 62, p. 1394 Journal of the Chemical Society, , vol. 121, p. 1793