NGR peptide

Modify Date: 2024-01-06 21:11:42

NGR peptide Structure
NGR peptide structure
Common Name NGR peptide
CAS Number 651328-78-8 Molecular Weight 608.69200
Density N/A Boiling Point N/A
Molecular Formula C20H36N10O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NGR peptide


NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging[1][2].

 Names

Name 2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]acetic acid
Synonym More Synonyms

 NGR peptide Biological Activity

Description NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging[1][2].
Related Catalog
Target

CD13/aminopeptidase N (APN) receptor[1]

In Vivo NGR peptide (20 mg/kg; i.v.) 可用作肿瘤成像和早期诊断的潜在 SPECT 试剂[2]。 Animal Model: 4-6 weeks, BALB/c nude mice (HepG2 tumor model)[2] Dosage: 20 mg/kg Administration: I.v. Result: Blocked the tumor uptake for 99mTc-NGR.
References

[1]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.  

[2]. Ma W, et al. Biodistribution and SPECT imaging study of (99m)Tc labeling NGR peptide in nude mice bearing human HepG2 hepatoma. Biomed Res Int. 2014;2014:618096.  

 Chemical & Physical Properties

Molecular Formula C20H36N10O8S2
Molecular Weight 608.69200
Exact Mass 608.21600
PSA 409.85000
LogP 1.32580

 Synonyms

NGR peptide
Glycine,L-cysteinyl-L-asparaginylglycyl-L-arginyl-L-cysteinyl
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