651328-78-8

651328-78-8 structure

Name: NGR peptide
Chemical Name: 2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]acetic acid
CAS Number: 651328-78-8
Molecular Formula: C₂₀H₃₆N₁₀O₈S₂
Molecular Weight: 608.69200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aminopeptidase
Create Date: 2016-05-05 04:48:55
Modify Date: 2024-01-06 21:11:42
NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging[1][2].

Name	2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]acetic acid
Synonyms	NGR peptide Glycine,L-cysteinyl-L-asparaginylglycyl-L-arginyl-L-cysteinyl

Description	NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase
Target	CD13/aminopeptidase N (APN) receptor[1]
In Vivo	NGR peptide (20 mg/kg; i.v.) 可用作肿瘤成像和早期诊断的潜在 SPECT 试剂[2]。 Animal Model: 4-6 weeks, BALB/c nude mice (HepG2 tumor model)[2] Dosage: 20 mg/kg Administration: I.v. Result: Blocked the tumor uptake for 99mTc-NGR.
References	[1]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46. [2]. Ma W, et al. Biodistribution and SPECT imaging study of (99m)Tc labeling NGR peptide in nude mice bearing human HepG2 hepatoma. Biomed Res Int. 2014;2014:618096.