852805-92-6

852805-92-6 structure

Name: TRAF6 Peptide trifluoroacetate salt
Chemical Name: TRAF6 Peptide trifluoroacetate salt
CAS Number: 852805-92-6
Molecular Formula: C₁₄₅H₂₃₈N₃₄O₄₄
Molecular Weight: 3161.643
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2021-01-06 18:04:22
Modify Date: 2024-01-10 13:14:55
TRAF6 peptide is a specific TRAF6-p62 inhibitor. TRAF6 peptide potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke[1].

Name	TRAF6 Peptide trifluoroacetate salt
Synonyms	L-Lysine, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-α-glutamyl-L-seryl-L-alanyl-L-serylglycyl- L-prolyl-L-seryl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-seryl-L-valyl-L-asparaginyl-L-phenylalanyl-L-leucyl- L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-α-glutamyl-L-seryl-L-alanyl-L-serylglycyl-L-prolyl-L -seryl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-seryl-L-valyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-lysine

Description	TRAF6 peptide is a specific TRAF6-p62 inhibitor. TRAF6 peptide potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme Research Areas >> Neurological Disease
In Vitro	TRAF6 peptide (150 µM; 5 h) blocks the interaction of p62 with TRAF6 in PC12 cells[1]. TRAF6 peptide eliminates TRAF6 and UbcH7 from interacting with TrkA and can ffectively abolish NGF-dependent ubiquitination of TrkA in vitro[1]. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 150 µM Incubation Time: 5 h Result: Inhibited the interaction of p62 with TRAF6 by immunoprecipitating TRA F6.
References	[1]. Wooten, Marie W. Substances interfering with TRAF6-p62 interaction for inhibiting intracellular aggregate formation and methods for screening for such substances. Patent WO2005050170A2.