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NGR peptide

Names

[ CAS No. ]:
651328-78-8

[ Name ]:
NGR peptide

[Synonym ]:
NGR peptide
Glycine,L-cysteinyl-L-asparaginylglycyl-L-arginyl-L-cysteinyl

Biological Activity

[Description]:

NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase

[Target]

CD13/aminopeptidase N (APN) receptor[1]


[In Vivo]

NGR peptide (20 mg/kg; i.v.) 可用作肿瘤成像和早期诊断的潜在 SPECT 试剂[2]。 Animal Model: 4-6 weeks, BALB/c nude mice (HepG2 tumor model)[2] Dosage: 20 mg/kg Administration: I.v. Result: Blocked the tumor uptake for 99mTc-NGR.

[References]

[1]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.  

[2]. Ma W, et al. Biodistribution and SPECT imaging study of (99m)Tc labeling NGR peptide in nude mice bearing human HepG2 hepatoma. Biomed Res Int. 2014;2014:618096.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H36N10O8S2

[ Molecular Weight ]:
608.69200

[ Exact Mass ]:
608.21600

[ PSA ]:
409.85000

[ LogP ]:
1.32580

Related Compounds