LH846
Modify Date: 2024-01-04 17:30:03
LH846 structure
|
Common Name | LH846 | ||
|---|---|---|---|---|
| CAS Number | 639052-78-1 | Molecular Weight | 316.805 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H13ClN2OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of LH846LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively. |
| Name | N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide |
|---|---|
| Synonym | More Synonyms |
| Description | LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
CKIδ:290 nM (IC50) CKIϵ:1.3 μM (IC50) CKIα:2.5 μM (IC50) |
| In Vitro | LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H13ClN2OS |
| Molecular Weight | 316.805 |
| Exact Mass | 316.043701 |
| PSA | 73.72000 |
| LogP | 4.67 |
| Appearance of Characters | white solid |
| Index of Refraction | 1.709 |
| Storage condition | -20℃ |
| N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide |
| Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl)- |
| LH-846 |
| LH846 |