639052-78-1
639052-78-1 structure
- Name: LH846
- Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide
- CAS Number: 639052-78-1
- Molecular Formula: C16H13ClN2OS
- Molecular Weight: 316.805
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2017-09-18 16:18:29
- Modify Date: 2024-01-04 17:30:03
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LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
| Name | N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide |
|---|---|
| Synonyms |
N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl)- LH-846 LH846 |
| Description | LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
CKIδ:290 nM (IC50) CKIϵ:1.3 μM (IC50) CKIα:2.5 μM (IC50) |
| In Vitro | LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H13ClN2OS |
| Molecular Weight | 316.805 |
| Exact Mass | 316.043701 |
| PSA | 73.72000 |
| LogP | 4.67 |
| Appearance | white solid |
| Index of Refraction | 1.709 |
| Storage condition | -20℃ |
