LH846

Names

[ Name ]:
LH846

[Synonym ]:
N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl)-
LH-846
LH846

Biological Activity

[Description]:

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

Research Areas >> Cancer

[Target]

CKIδ:290 nM (IC50)

CKIϵ:1.3 μM (IC50)

CKIα:2.5 μM (IC50)

[In Vitro]

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].

[References]

[1]. Lee JW, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.

[Related Small Molecules]

Silmitasertib (CX-4945) | D4476 | TBB | DMAT | Emodin | PF-670462 | SR 3029 | IC 261 | TA-01 | Ellagic acid | TTP 22 | Casein Kinase II Inhibitor IV | PF 4800567

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₁₃ClN₂OS

[ Molecular Weight ]:
316.805

[ Exact Mass ]:
316.043701

[ PSA ]:
73.72000

[ LogP ]:
4.67

[ Appearance of Characters ]:
white solid

[ Index of Refraction ]:
1.709

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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