TTP 22

Names

[ Name ]:
TTP 22

[Synonym ]:
3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid
TTP-22
Propanoic acid, 3-[[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]-
HMS1423O22
3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid
TTP22
TTP 22

Biological Activity

[Description]:

TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

CK2:100 nM (IC50)

[In Vitro]

TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM. TTP 22 shows no effect on other kianses such as Jnk3, Rock1, Tie2, Ask1, Met and FGFR1 at 10 μM[1].

[References]

[1]. Golub AG, et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6.

[Related Small Molecules]

Silmitasertib (CX-4945) | D4476 | TBB | DMAT | Emodin | PF-670462 | SR 3029 | IC 261 | TA-01 | Ellagic acid | LH846 | Casein Kinase II Inhibitor IV | PF 4800567

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
575.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O₂S₂

[ Molecular Weight ]:
330.425

[ Flash Point ]:
301.6±30.1 °C

[ Exact Mass ]:
330.049683

[ PSA ]:
116.62000

[ LogP ]:
4.21

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.710

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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