Pramoxine HCl

Modify Date: 2025-08-20 07:04:17

Pramoxine HCl structure	Common Name	Pramoxine HCl
	CAS Number	637-58-1	Molecular Weight	329.862
	Density	N/A	Boiling Point	427ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₈ClNO₃	Melting Point	181-183ºC
	MSDS	Chinese USA	Flash Point	123.5ºC
	Symbol	GHS07	Signal Word	Warning

Use of Pramoxine HCl

Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic.

Name	Pramoxine hydrochloride
Synonym	More Synonyms

Description	Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease

Boiling Point	427ºC at 760 mmHg
Melting Point	181-183ºC
Molecular Formula	C₁₇H₂₈ClNO₃
Molecular Weight	329.862
Flash Point	123.5ºC
Exact Mass	329.175781
PSA	30.93000
LogP	3.70650

Pramoxine HCl MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD8750000

CHEMICAL NAME :: Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride

CAS REGISTRY NUMBER :: 637-58-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H27-N-O3.Cl-H

MOLECULAR WEIGHT :: 329.91

WISWESSER LINE NOTATION :: T6N DOTJ A3OR DO4 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,454,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80493 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80493 No. of Facilities: 98 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 16892 (estimated) No. of Female Employees: 15582 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
RTECS	QD8750000
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A case of "contact allergy to corticosteroid.".

Contact Dermatitis 28(1) , 39-40, (1993)

Perioral dermatitis.

Acta Dermatovenerol. Croat. 16(2) , 96-100, (2008)

Perioral dermatitis is an inflammatory facial skin disorder that predominantly affects women. It is rarely diagnosed in children. The etiology of perioral dermatitis is unknown; however, uncritical us...

The safety of pramoxine hydrochloride when used as a topical (surface) anesthetic.

Cutis. 62(3) , 122-3, (1998)

p-Butoxyphenyl g-Morpholinopropyl Ether Hydrochloride

proctofoam

p-Butoxyphenyl γ-morpholinopropyl ether hydrochloride

g-Morpholinopropyl 4-n-Butoxyphenyl Ether Hydrochloride

Morpholine, 4-[3- (4-butoxyphenoxy)propyl]-, hydrochloride

EINECS 211-293-1

γ-Morpholinopropyl 4-N-butoxyphenyl ether hydrochloride

Morpholine, 4-[3- (p-butoxyphenoxy)propyl]-, hydrochloride

Pramoxine hydrochloride

4-[3-(4-Butoxyphenoxy)propyl]morpholine Hydrochloride

Tronothane hydrochloride

4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride (1:1)

pramoxine HCl

4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride

MFCD00054323

Proxazocain Hydrochloride

4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride

Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)

Pramocaine (hydrochloride)

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China
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pramoxine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 637-58-1
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
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Price: $66/10mM*1mLinDMSO

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Pramoxine HCl

Use of Pramoxine HCl

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Pramoxine HCl Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

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Synonyms

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