Pramoxine HCl

Names

[ CAS No. ]:
637-58-1

[ Name ]:
Pramoxine HCl

[Synonym ]:
p-Butoxyphenyl g-Morpholinopropyl Ether Hydrochloride
proctofoam
p-Butoxyphenyl γ-morpholinopropyl ether hydrochloride
g-Morpholinopropyl 4-n-Butoxyphenyl Ether Hydrochloride
Morpholine, 4-[3- (4-butoxyphenoxy)propyl]-, hydrochloride
EINECS 211-293-1
γ-Morpholinopropyl 4-N-butoxyphenyl ether hydrochloride
Morpholine, 4-[3- (p-butoxyphenoxy)propyl]-, hydrochloride
Pramoxine hydrochloride
4-[3-(4-Butoxyphenoxy)propyl]morpholine Hydrochloride
Tronothane hydrochloride
4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride (1:1)
pramoxine HCl
4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride
MFCD00054323
Proxazocain Hydrochloride
4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride
Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)
Pramocaine (hydrochloride)

Biological Activity

[Description]:

Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
427ºC at 760 mmHg

[ Melting Point ]:
181-183ºC

[ Molecular Formula ]:
C₁₇H₂₈ClNO₃

[ Molecular Weight ]:
329.862

[ Flash Point ]:
123.5ºC

[ Exact Mass ]:
329.175781

[ PSA ]:
30.93000

[ LogP ]:
3.70650

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD8750000

CHEMICAL NAME :: Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride

CAS REGISTRY NUMBER :: 637-58-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H27-N-O3.Cl-H

MOLECULAR WEIGHT :: 329.91

WISWESSER LINE NOTATION :: T6N DOTJ A3OR DO4 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,454,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80493 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80493 No. of Facilities: 98 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 16892 (estimated) No. of Female Employees: 15582 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QD8750000

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A case of "contact allergy to corticosteroid.".

Contact Dermatitis 28(1) , 39-40, (1993)

Perioral dermatitis.

Acta Dermatovenerol. Croat. 16(2) , 96-100, (2008)

Perioral dermatitis is an inflammatory facial skin disorder that predominantly affects women. It is rarely diagnosed in children. The etiology of perioral dermatitis is unknown; however, uncritical us...

The safety of pramoxine hydrochloride when used as a topical (surface) anesthetic.

Cutis. 62(3) , 122-3, (1998)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.