[D- MET2 , PRO5 ]-ENKEPHALINAMIDE

Modify Date: 2025-08-26 15:57:10

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure
[D- MET2 , PRO5 ]-ENKEPHALINAMIDE structure
 Common Name [D- MET2 , PRO5 ]-ENKEPHALINAMIDE
CAS Number 63307-63-1 Molecular Weight 612.74000
Density 1.31g/cm3 Boiling Point 1065ºC at 760 mmHg
Molecular Formula C30H40N6O6S Melting Point N/A
MSDS N/A Flash Point 597.9ºC

 Use of [D- MET2 , PRO5 ]-ENKEPHALINAMIDE


(D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity[1][2][3].

 Names

Name 1-[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxamide
Synonym More Synonyms

 [D- MET2 , PRO5 ]-ENKEPHALINAMIDE Biological Activity

Description (D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity[1][2][3].
Related Catalog
In Vivo (D-Met2,Pro5)-Enkephalinamide (intravenous injection; 0.25 and 0.5 mg/kg; once) leads to the decreasement of prolactin (PRL) secretion in lactating rats[2]. Animal Model: Wistar lactating rats[2] Dosage: 0.25 and 0.5 mg/kg Administration: Intravenous injection; 0.25 and 0.5 mg/kg; once Result: Decreased plasma PRL levels 15 min after the administration in continuously lactating rats. Produced a marked depression in plasma PRL concentration in non-deprived lactating mothers.

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 1065ºC at 760 mmHg
Molecular Formula C30H40N6O6S
Molecular Weight 612.74000
Flash Point 597.9ºC
Exact Mass 612.27300
PSA 233.71000
LogP 4.12870
Index of Refraction 1.616

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3583000
CHEMICAL NAME :
L-Prolinamide, L-tyrosyl-D-methionylglycyl-L-phenylalanyl-
CAS REGISTRY NUMBER :
63307-63-1
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C30-H40-N6-O6-S
MOLECULAR WEIGHT :
612.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987

 Synthetic Route

Boc Tyr D.Met Gly Phe Pro NH2 structure

Boc Tyr D.Met G...

CAS#:66864-05-9

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
Boc-L-phenylalanine structure

Boc-L-phenylalanine

CAS#:13734-34-4

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
N-Boc-L-Phe-L-Pro methyl ester structure

N-Boc-L-Phe-L-P...

CAS#:38017-89-9

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
methyl (tert-butoxycarbonyl)-L-tyrosyl-D-methionylglycinate structure

methyl (tert-bu...

CAS#:70777-31-0

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
N-(tert-Butyloxycarbonyl)-L-tyrosyl-D-methionine structure

N-(tert-Butylox...

CAS#:108329-67-5

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
Boc-L-Tyr-D-Met-OMe structure

Boc-L-Tyr-D-Met-OMe

CAS#:82558-39-2

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
Boc-(L)(α-Me)Tyr-OH structure

Boc-(L)(α-Me)Tyr-OH

CAS#:74825-83-5

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
Boc Tyr D.Met Gly OH structure

Boc Tyr D.Met Gly OH

CAS#:69612-72-2

~%

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE Structure

[D- MET2 , PRO5...

CAS#:63307-63-1

Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177

 Synonyms

H-Tyr-D-Met-Gly-Phe-Pro-NH2
L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-L-proline amide
Tyr-D-Met-Gly-Phe-Pro-NH2
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Chemsrc provides [D- MET2 , PRO5 ]-ENKEPHALINAMIDE(CAS#:63307-63-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of [D- MET2 , PRO5 ]-ENKEPHALINAMIDE are included as well.>> amp version: [D- MET2 , PRO5 ]-ENKEPHALINAMIDE

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