Hydroxychloroquine Impurity F

Modify Date: 2024-01-02 10:55:38

Hydroxychloroquine Impurity F structure	Common Name	Hydroxychloroquine Impurity F
	CAS Number	6281-58-9	Molecular Weight	246.73500
	Density	1.214g/cm3	Boiling Point	392.5ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₅ClN₂	Melting Point	N/A
	MSDS	N/A	Flash Point	191.2ºC

Use of Hydroxychloroquine Impurity F

Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

Name	7-chloro-4-(2-methylpyrrolidin-1-yl)quinoline
Synonym	More Synonyms

Description	Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Density	1.214g/cm3
Boiling Point	392.5ºC at 760 mmHg
Molecular Formula	C₁₄H₁₅ClN₂
Molecular Weight	246.73500
Flash Point	191.2ºC
Exact Mass	246.09200
PSA	16.13000
LogP	3.94190
Index of Refraction	1.626
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB3329000

CHEMICAL NAME :: Quinoline, 7-chloro-4-(2-methylpyrrolidinyl)-

CAS REGISTRY NUMBER :: 6281-58-9

BEILSTEIN REFERENCE NO. :: 0203557

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H15-Cl-N2

MOLECULAR WEIGHT :: 246.76

WISWESSER LINE NOTATION :: T66 BNJ IG E- AT5NTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00357

nx 357

4-(2-Methyl-1-Pyrrolidyl)-7-Chloroquinoline

Plaquenil Impurity 2

DC Chemicals Limited
China
Product Name: Hydroxychloroquine Impurity F
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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