6281-58-9

6281-58-9 structure

Name: Hydroxychloroquine Impurity F
Chemical Name: 7-chloro-4-(2-methylpyrrolidin-1-yl)quinoline
CAS Number: 6281-58-9
Molecular Formula: C₁₄H₁₅ClN₂
Molecular Weight: 246.73500
Catalog: Research Areas Others
Create Date: 2017-03-08 15:49:57
Modify Date: 2025-08-25 11:02:18
Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

Name	7-chloro-4-(2-methylpyrrolidin-1-yl)quinoline
Synonyms	nx 357 4-(2-Methyl-1-Pyrrolidyl)-7-Chloroquinoline Plaquenil Impurity 2

Description	Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00357