Hydroxychloroquine Impurity E

Modify Date: 2024-01-03 23:23:10

Hydroxychloroquine Impurity E structure	Common Name	Hydroxychloroquine Impurity E
	CAS Number	10500-64-8	Molecular Weight	264.75100
	Density	1.248g/cm3	Boiling Point	453.7ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₇ClN₂O	Melting Point	179-181 ºC
	MSDS	N/A	Flash Point	N/A

Use of Hydroxychloroquine Impurity E

Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

Name	4-[(7-chloroquinolin-4-yl)amino]pentan-1-ol
Synonym	More Synonyms

Description	Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Density	1.248g/cm3
Boiling Point	453.7ºC at 760 mmHg
Melting Point	179-181 ºC
Molecular Formula	C₁₄H₁₇ClN₂O
Molecular Weight	264.75100
Exact Mass	264.10300
PSA	45.15000
LogP	3.53410
Vapour Pressure	5.08E-09mmHg at 25°C
Index of Refraction	1.643
Water Solubility	Practically insoluble (0.087 g/L) (25 ºC)

HS Code	2933499090

4,7-Dichloroqui...

CAS#:86-98-6

Hydroxychloroqu...

CAS#:10500-64-8

Literature: Journal of the American Chemical Society, , vol. 68, p. 1224

Precursor 1
CAS#:86-98-6 4,7-Dichloroqui...
DownStream 0

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

GNF-Pf-1978

4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol

Plaquenil Impurity 1

DC Chemicals Limited
China
Product Name: Hydroxychloroquine Impurity E
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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