VEGFR-2-IN-29

Modify Date: 2024-01-10 12:19:49

VEGFR-2-IN-29 Structure
VEGFR-2-IN-29 structure
Common Name VEGFR-2-IN-29
CAS Number 62802-77-1 Molecular Weight 293.27700
Density N/A Boiling Point N/A
Molecular Formula C16H11N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VEGFR-2-IN-29


VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].

 Names

Name 3-nitro-N-quinolin-8-ylbenzamide
Synonym More Synonyms

 VEGFR-2-IN-29 Biological Activity

Description VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].
Related Catalog
Target

VEGFR-2:16.5 nM (IC50)

In Vitro VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1]. Cell Proliferation Assay[1] Cell Line: HUVEC Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.
References

[1]. Yang Y, et al. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6653-6.

 Chemical & Physical Properties

Molecular Formula C16H11N3O3
Molecular Weight 293.27700
Exact Mass 293.08000
PSA 91.30000
LogP 4.30250

 Synonyms

3-Nitro-N-(8-chinolinyl)benzamid
3-Nitro-N-quinolin-8-yl-benzamide