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2447587-73-5

2447587-73-5 structure

2447587-73-5 structure

Name: VEGFR-2-IN-22
Chemical Name: VEGFR-2-IN-22
CAS Number: 2447587-73-5
Molecular Formula: C₂₆H₂₄ClFN₄O₆
Molecular Weight: 542.94
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-21 11:28:27
Modify Date: 2025-09-06 10:45:06
VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].

Name	VEGFR-2-IN-22

Description	VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR2:19.82 nM (IC50)
In Vitro	VEGFR-2-IN-22 (Compound 25) shows inhibition with an IC50 of 0.24 ± 0.06 µM against HepG2[1].
References	[1]. Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Aug;101:103995.

Molecular Formula	C₂₆H₂₄ClFN₄O₆
Molecular Weight	542.94

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