2411174-53-1

2411174-53-1 structure

2411174-53-1 structure

Name: VEGFR-2-IN-23
Chemical Name: VEGFR-2-IN-23
CAS Number: 2411174-53-1
Molecular Formula: C₂₂H₁₅N₅O₂
Molecular Weight: 381.39
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-17 20:44:57
Modify Date: 2024-01-14 12:03:37
VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

Name	VEGFR-2-IN-23

Description	VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR-2:0.19 nM (IC50)
In Vitro	VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC50s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively[1].
In Vivo	VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models[1].
References	[1]. AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222.

Molecular Formula	C₂₂H₁₅N₅O₂
Molecular Weight	381.39