BMS-582949
Modify Date: 2024-01-11 10:15:24
BMS-582949 structure
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Common Name | BMS-582949 | ||
|---|---|---|---|---|
| CAS Number | 623152-17-0 | Molecular Weight | 406.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H26N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-582949BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1]. |
| Name | 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1]. |
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| Related Catalog | |
| Target |
p38α:13 nM (IC50) |
| References |
| Molecular Formula | C22H26N6O2 |
|---|---|
| Molecular Weight | 406.48 |
| Exact Mass | 406.21200 |
| PSA | 110.63000 |
| LogP | 3.69320 |
| Storage condition | -20℃ |
|
~94%
BMS-582949 CAS#:623152-17-0 |
| Literature: Kim, Soojin; Malley, Mary F.; Shi, Zhongping Patent: US2006/235020 A1, 2006 ; Location in patent: Page/Page column 22-23 ; |
|
~88%
BMS-582949 CAS#:623152-17-0 |
| Literature: Cann, Reginald O.; Delaney, Edward J.; Fan, Junying; Parlanti, Luca Patent: US2006/35886 A1, 2006 ; Location in patent: Page/Page column 13 ; US 20060035886 A1 |
![ethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate structure](https://www.chemsrc.com/caspic/489/623152-11-4.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 38P |
| 3mvl |
| UNII-CR743OME9E |
| BMS-582949 |
| BMS-582949 HCl |