BMS-582949

Names

[ Name ]:
BMS-582949

[Synonym ]:
38P
3mvl
UNII-CR743OME9E
BMS-582949
BMS-582949 HCl

Biological Activity

[Description]:

BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

[Target]

p38α:13 nM (IC50)

[References]

[1]. Liu C, et al. Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. J Med Chem. 2010 Sep 23;53(18):6629-39.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆N₆O₂

[ Molecular Weight ]:
406.48

[ Exact Mass ]:
406.21200

[ PSA ]:
110.63000

[ LogP ]:
3.69320

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.