Methacholine (chloride)

Modify Date: 2024-01-02 19:09:09

Methacholine (chloride) structure	Common Name	Methacholine (chloride)
	CAS Number	62-51-1	Molecular Weight	195.687
	Density	1.1028 (rough estimate)	Boiling Point	N/A
	Molecular Formula	C₈H₁₈ClNO₂	Melting Point	171-173ºC(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Methacholine (chloride)

Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.

Name	Acetyl-beta-methylcholine chloride
Synonym	More Synonyms

Description	Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Others
References	[1]. Birnbaum S, et al. Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement. Chest. 2007 Jun;131(6):1932-5.

Density	1.1028 (rough estimate)
Melting Point	171-173ºC(lit.)
Molecular Formula	C₈H₁₈ClNO₂
Molecular Weight	195.687
Exact Mass	195.102600
PSA	26.30000
Index of Refraction	1.5790 (estimate)
Stability	Unstable - moisture sensitive. Incompatible with oxidizing agents.
Water Solubility	H2O: 50 mg/mL, clear, colorless \| almost transparency

Methacholine (chloride) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BR5250000

CHEMICAL NAME :: Ammonium, (2-hydroxypropyl)trimethyl-, chloride, acetate

CAS REGISTRY NUMBER :: 62-51-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H18-N-O2.Cl

MOLECULAR WEIGHT :: 195.72

WISWESSER LINE NOTATION :: 1VOY1&1K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,210,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3750 ug/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,245,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2961 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 307 (estimated) No. of Female Employees: 162 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BR5250000
HS Code	29239000

Ethanoic anhydride

CAS#:108-24-7

BETA-METHYLCHOL...

CAS#:2382-43-6

Methacholine (c...

CAS#:62-51-1

Literature: Journal of the American Chemical Society, , vol. 54, p. 242 US2040146 , ; US2040145 , ;

Precursor 2
CAS#:108-24-7 Ethanoic anhydride CAS#:2382-43-6 BETA-METHYLCHOL...
DownStream 0

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury.

Am. J. Physiol. Lung Cell. Mol. Physiol. 308 , L891-903, (2015)

Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts with epithelial lining fluid, forming by-...

MAG-EPA and 17,18-EpETE target cytoplasmic signalling pathways to reduce short-term airway hyperresponsiveness.

Pflugers Arch. 467 , 1591-605, (2015)

This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuc...

Methacholinium chloride

Besacholine

Mechothane

1-propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride

Methacholine chloride

β-Methylcholine chloride urethan

Urecholine chloride

Uro-Carb

2-carbamoyloxypropyl(trimethyl)azanium,chloride

b-Methylacetylcholine Chloride

Acetyl-b-methylcholine Chloride

2-Acetoxy-N,N,N-trimethylpropan-1-aminium chloride

(2-Carbamoyloxy-propyl)-trimethyl-ammonium,Chlorid

2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium chloride

Carbamate of (2-Hydroxypropyl)trimethylammonium Chloride

Mictone

2-(acetyloxy)-N,N,N-trimethylpropan-1-aminium chloride

2-(Carbamoyloxy)-N,N,N-trimethyl-1-propanaminium chloride

2-[(aminocarbonyl)oxy]-N,N,N-trimethylpropan-1-aminium chloride

Carbamylmethylcholine chloride

Urecholine

2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium Chloride

(2-Carbamoyloxypropyl)trimethylammonium chloride

2-acetyloxypropyl(trimethyl)azanium,chloride

Bethanechol chloride

(2-carbamoyloxy-propyl)-trimethyl-ammonium,chloride

Trimethyl-b-acetoxypropylammonium Chloride

EINECS 200-537-2

Mechotane

O-Acetyl-b-methylcholine Chloride

BTC

Mecothane

2-carbamyloxy-1-(N,N,N-trimethyl)-propylammonium chloride

1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (1:1)

methylcarbachol chloride

UNII:0W5ETF9M2K

Bethanechol

1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1)

DUVOID

Myocholine

2-Acetoxy-N,N,N-trimethyl-1-propanaminium chloride

MFCD00011817

(±)-Acetyl-b-methylcholine Chloride

Methacholine (chloride)

DC Chemicals Limited
China
Product Name: Methacholine Chloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: methacholine chloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: METHACHOLINE CHLORIDE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Get all suppliers and price by the below link:

Methacholine (chloride) suppliers

Price: $79/10mM*1mLinDMSO

Reference only. check more Methacholine (chloride) price

Methacholine (chloride)

Use of Methacholine (chloride)

Names