BMS-585248
Modify Date: 2024-01-10 17:33:00
BMS-585248 structure
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Common Name | BMS-585248 | ||
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| CAS Number | 619331-12-3 | Molecular Weight | 447.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18FN7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-585248BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1]. |
| Name | 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione |
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| Synonym | More Synonyms |
| Description | BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1]. |
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| Related Catalog | |
| Target |
HIV-1 |
| In Vivo | BMS-585248 (静脉注射 (1 mg/kg) 和口服 (5-200 mg/kg); 一次)具有良好的药代动力学特征，雄性大鼠静脉注射 (1mg /kg) 和口服 (5mg /kg) 后，AUC 值分别为 3220 nM·h 和 8064 nM·h。 Animal Model: Male rats[1] Dosage: 5, 15, and 200 mg/kg Administration: Orally, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of BMS-585248 in male rats[1]. PO Dose (mg/kg) 15 75 200 Cmax (μM) 6.6 8.4 11 AUCtot (μM·h) 42 115 145 |
| References |
| Molecular Formula | C22H18FN7O3 |
|---|---|
| Molecular Weight | 447.42200 |
| Exact Mass | 447.14600 |
| PSA | 117.08000 |
| LogP | 1.32580 |
| unii-cio2tzz9h1 |