BMS-585248

Names

[ CAS No. ]:
619331-12-3

[ Name ]:
BMS-585248

[Synonym ]:
unii-cio2tzz9h1

Biological Activity

[Description]:

BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

HIV-1

[In Vivo]

BMS-585248 (静脉注射 (1 mg/kg) 和口服 (5-200 mg/kg); 一次)具有良好的药代动力学特征，雄性大鼠静脉注射 (1mg /kg) 和口服 (5mg /kg) 后，AUC 值分别为 3220 nM·h 和 8064 nM·h。 Animal Model: Male rats[1] Dosage: 5, 15, and 200 mg/kg Administration: Orally, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of BMS-585248 in male rats[1]. PO Dose (mg/kg) 15 75 200 Cmax (μM) 6.6 8.4 11 AUCtot (μM·h) 42 115 145

[References]

[1]. Regueiro-Ren A, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248. J Med Chem. 2013 Feb 28;56(4):1670-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₈FN₇O₃

[ Molecular Weight ]:
447.42200

[ Exact Mass ]:
447.14600

[ PSA ]:
117.08000

[ LogP ]:
1.32580

Related Compounds

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