AZ10606120 dihydrochloride

Modify Date: 2024-01-13 18:16:24

AZ10606120 dihydrochloride structure	Common Name	AZ10606120 dihydrochloride
	CAS Number	607378-18-7	Molecular Weight	495.485
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₆Cl₂N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AZ10606120 dihydrochloride

AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].

Name	N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
Synonym	More Synonyms

Description	AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
Target	IC50: ~10 nM (P2X7R)[1]
References	[1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.

Molecular Formula	C₂₅H₃₆Cl₂N₄O₂
Molecular Weight	495.485
Exact Mass	494.221527

2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride

2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]acetamide dihydrochloride

Tricyclo[3.3.1.1]decane-1-acetamide, N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-, hydrochloride (1:2)

DC Chemicals Limited
China
Product Name: AZ10606120 dihydrochloride
Price: $500.0/100mg $1000.0/250mg $2000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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