AZ10606120 dihydrochloride

Names

[ Name ]:
AZ10606120 dihydrochloride

[Synonym ]:
2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride
2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]acetamide dihydrochloride
Tricyclo[3.3.1.1]decane-1-acetamide, N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

Research Areas >> Neurological Disease

[Target]

IC50: ~10 nM (P2X7R)[1]

[References]

[1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₆Cl₂N₄O₂

[ Molecular Weight ]:
495.485

[ Exact Mass ]:
494.221527

Related Compounds

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