607378-18-7

607378-18-7 structure

Name: AZ10606120 dihydrochloride
Chemical Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
CAS Number: 607378-18-7
Molecular Formula: C₂₅H₃₆Cl₂N₄O₂
Molecular Weight: 495.485
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2017-12-11 00:20:40
Modify Date: 2024-01-13 18:16:24
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].

Name	N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
Synonyms	2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride 2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]acetamide dihydrochloride Tricyclo[3.3.1.1]decane-1-acetamide, N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-, hydrochloride (1:2)

Description	AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
Target	IC50: ~10 nM (P2X7R)[1]
References	[1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.