[Met5]enkephalin amide

Modify Date: 2025-08-27 19:54:58

[Met5]enkephalin amide structure	Common Name	[Met5]enkephalin amide
	CAS Number	60117-17-1	Molecular Weight	572.67600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₆N₆O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [Met5]enkephalin amide

[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

Name	[Met5]enkephalin amide
Synonym	More Synonyms

Description	[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Peptides Research Areas >> Neurological Disease
Target	δ and ζ opioid receptor[1]
In Vitro	[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
References	[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.

YGGFM-NH2

[Met-NH2]5-enkephalin

(Met5)-enkephalinamide

Met5-enkephallin amide

methionine enkephalinamide

Met-enkephalin amide

[MET5]-ENKEPHALIN AMIDE

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