Phloretin

Modify Date: 2024-01-02 21:00:36

Phloretin Structure
Phloretin structure
 Common Name Phloretin
CAS Number 60-82-2 Molecular Weight 274.269
Density 1.4±0.1 g/cm3 Boiling Point 534.4±29.0 °C at 760 mmHg
Molecular Formula C15H14O5 Melting Point ~260 °C
MSDS Chinese USA Flash Point 291.1±20.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Phloretin


Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].

 Names

Name phloretin
Synonym More Synonyms

 Phloretin Biological Activity

Description Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].
Related Catalog
References

[1]. CHAN SS, LOTSPEICH WD. Comparative effects of phlorizin and phloretin on glucose transport in the cat kidney. Am J Physiol. 1962 Dec;203:975-9.

[2]. Huang WC, Chang WT, Wu SJ, Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures. Mol Nutr Food Res. 2013 Jun 17.

[3]. Luo H, Wang YJ, Chen J, Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.

[4]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.

[5]. Najafian M, Jahromi MZ, Nowroznejhad MJ, Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Mol Biol Rep. 2012 May;39(5):5299-306.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 534.4±29.0 °C at 760 mmHg
Melting Point ~260 °C
Molecular Formula C15H14O5
Molecular Weight 274.269
Flash Point 291.1±20.8 °C
Exact Mass 274.084137
PSA 97.99000
LogP 3.50
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.685
Storage condition 2-8°C
Water Solubility soluble

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles94

More Articles
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.

Oncotarget 6 , 37281-99, (2015)

Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance. Cancer cells have metabolic flexibility in ch...
Antagonistic control of a dual-input mammalian gene switch by food additives.

Nucleic Acids Res. 42(14) , e116, (2014)

Synthetic biology has significantly advanced the design of mammalian trigger-inducible transgene-control devices that are able to programme complex cellular behaviour. Fruit-based benzoate derivatives...
Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

 Synonyms

QR CQ EQ BV2R DQ
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
Dihydronaringenin
2',4',6',4-tetrahydroxydihydrochalcone
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
β-(p-Hydroxyphenyl)phloropropiophenone
phloretol
4,2',4',6'-tetrahydroxydihydrochalcone
b-(p-Hydroxyphenyl)phloropropiophenone
UNII-S5J5OE47MK
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
EINECS 200-488-7
Phloretin
MFCD00002288
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Phloretin
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

Get all suppliers and price by the below link:

Phloretin suppliers

Price: ￥92.1/5g

Reference only. check more Phloretin price

Related Compounds: More...
phloretin triacetate
42385-89-7
phloretin-4-D-glucoside
4192-90-9
phloretin 2'-O-glucoside
60-81-1
PHLORETIN-4-METHYL ETHER
76172-68-4
PHLORETIN-4-METHYL ETHER
59108-68-8
Phloretin 4'-methyl ether
520-42-3
Phloretin 2'-O-rhamnoside
19253-17-9
PHLORETIN-4,4'-DIMETHYL ETHER
35241-54-4
Phloretin 3',5'-Di-C-glucoside
357401-40-2
Chemsrc provides Phloretin(CAS#:60-82-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Phloretin are included as well.>> amp version: Phloretin

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved