Manool
Manool structure
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Common Name | Manool | ||
|---|---|---|---|---|
| CAS Number | 596-85-0 | Molecular Weight | 290.48300 | |
| Density | 0.93g/cm3 | Boiling Point | 368.2ºC at 760mmHg | |
| Molecular Formula | C20H34O | Melting Point | 49-52ºC(lit.) | |
| MSDS | N/A | Flash Point | 118.2ºC | |
Use of ManoolManool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2]. |
| Name | manool |
|---|---|
| Synonym | More Synonyms |
| Description | Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2]. |
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| Related Catalog | |
| In Vitro | Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3]. |
| References |
[2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. |
| Density | 0.93g/cm3 |
|---|---|
| Boiling Point | 368.2ºC at 760mmHg |
| Melting Point | 49-52ºC(lit.) |
| Molecular Formula | C20H34O |
| Molecular Weight | 290.48300 |
| Flash Point | 118.2ºC |
| Exact Mass | 290.26100 |
| PSA | 20.23000 |
| LogP | 5.50240 |
| Index of Refraction | 1.5 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| WGK Germany | 3 |
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~91%
Manool CAS#:596-85-0 |
| Literature: Rogachev, Victor; Loehl, Thorsten; Markert, Thomas; Metz, Peter Arkivoc, 2012 , vol. 2012, # 3 p. 172 - 180 |
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~15%
Manool CAS#:596-85-0
Manool CAS#:596-85-0 |
| Literature: Organic and Biomolecular Chemistry, , vol. 9, # 7 p. 2156 - 2165 |
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Manool CAS#:596-85-0 |
| Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180 |
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Manool CAS#:596-85-0 |
| Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180 |
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~%
Manool CAS#:596-85-0 |
| Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 453 - 458 |
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Manool CAS#:596-85-0 |
| Literature: Agricultural and Biological Chemistry, , vol. 46, # 10 p. 2477 - 2484 |
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Detail
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| Literature: Justus Liebigs Annalen der Chemie, , vol. 617, p. 134 Journal of the Chemical Society, , p. 2187,2189 |
![(3R,4aS,6aR,10aR,10bS)-3-ethenyl-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydro-1H-benzo[f]chromene structure](https://image.chemsrc.com/caspic/327/596-84-9.png)
| Precursor 7 | |
|---|---|
| DownStream 6 | |
CAS#:3243-36-5
CAS#:511-15-9
CAS#:1232-00-4
CAS#:2584-47-6
CAS#:641-91-8| 8,14-labdadien-13-ol |
| MFCD01310996 |
| MANOOL |