596-85-0

596-85-0 structure

Name: Manool
Chemical Name: manool
CAS Number: 596-85-0
Molecular Formula: C₂₀H₃₄O
Molecular Weight: 290.48300
Catalog: Natural product Lignans
Create Date: 2018-09-17 13:39:12
Modify Date: 2025-08-20 17:24:48
Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].

Name	manool
Synonyms	8,14-labdadien-13-ol MFCD01310996 MANOOL

Description	Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].
References	[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.

22628-62-2

~91%

596-85-0

Literature: Rogachev, Victor; Loehl, Thorsten; Markert, Thomas; Metz, Peter Arkivoc, 2012 , vol. 2012, # 3 p. 172 - 180

6699-20-3

~15%

596-85-0

10395-43-4

Literature: Organic and Biomolecular Chemistry, , vol. 9, # 7 p. 2156 - 2165

515-03-7

596-85-0

Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180

54274-72-5

596-85-0

Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180

112239-38-0

596-85-0

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 453 - 458

515-03-7

596-84-9

10266-75-8

596-85-0

Literature: Agricultural and Biological Chemistry, , vol. 46, # 10 p. 2477 - 2484

515-03-7

108-24-7

64-19-7

84026-14-2

Detail

Literature: Justus Liebigs Annalen der Chemie, , vol. 617, p. 134 Journal of the Chemical Society, , p. 2187,2189