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Manool

Names

[ CAS No. ]:
596-85-0

[ Name ]:
Manool

[Synonym ]:
8,14-labdadien-13-ol
MFCD01310996
MANOOL

Biological Activity

[Description]:

Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].

[References]

[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143.

[2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290.

[3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.

Chemical & Physical Properties

[ Density]:
0.93g/cm3

[ Boiling Point ]:
368.2ºC at 760mmHg

[ Melting Point ]:
49-52ºC(lit.)

[ Molecular Formula ]:
C20H34O

[ Molecular Weight ]:
290.48300

[ Flash Point ]:
118.2ºC

[ Exact Mass ]:
290.26100

[ PSA ]:
20.23000

[ LogP ]:
5.50240

[ Index of Refraction ]:
1.5

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream