(3S)-3-Isobutyl-2,5-piperazinedione

Modify Date: 2025-08-25 14:41:49

(3S)-3-Isobutyl-2,5-piperazinedione structure	Common Name	(3S)-3-Isobutyl-2,5-piperazinedione
	CAS Number	5845-67-0	Molecular Weight	170.209
	Density	1.0±0.1 g/cm3	Boiling Point	442.9±38.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₄N₂O₂	Melting Point	255ºC
	MSDS	USA	Flash Point	207.4±26.9 °C

Use of (3S)-3-Isobutyl-2,5-piperazinedione

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].

Name	cyclo(-leu-gly)
Synonym	More Synonyms

Description	Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine Receptor
In Vivo	Cyclo(glycyl-L-leucyl) (8 mg/kg; 皮下给药) 在阿扑吗啡 (APO) 后 24 小时给予，可减弱由急性高剂量 APO (5 mg/kg; 皮下给药) 引起的 DA 受体超敏反应[1]。 Animal Model: Male Swiss-Webster mice, 20-25g[1] Dosage: 8 mg/kg Administration: SC; single dose given 24h after apomorphine (APO) Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).
References	[1]. J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity--inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11. [2]. H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23.

Density	1.0±0.1 g/cm3
Boiling Point	442.9±38.0 °C at 760 mmHg
Melting Point	255ºC
Molecular Formula	C₈H₁₄N₂O₂
Molecular Weight	170.209
Flash Point	207.4±26.9 °C
Exact Mass	170.105530
PSA	58.20000
LogP	-0.66
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.453

L-Leucylglycine diketopiperazine

MORPHINE TOLERANCE PEPTIDE

(3S)-3-Isobutyl-2,5-piperazinedione

2,5-Piperazinedione, 3-(2-methylpropyl)-, (3S)-

MORPHIN,TOLERANCE PEPTIDE

Cyclo(Leu-Gly)

3-isobutylpiperazine-2,5-quinone

(3S)-3-Isobutylpiperazine-2,5-dione

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Product Name: Cyclo（-Leu-Gly）
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(3S)-3-Isobutyl-2,5-piperazinedione

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.