5845-67-0

5845-67-0 structure

Name: (3S)-3-Isobutyl-2,5-piperazinedione
Chemical Name: cyclo(-leu-gly)
CAS Number: 5845-67-0
Molecular Formula: C₈H₁₄N₂O₂
Molecular Weight: 170.209
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-03-29 08:00:00
Modify Date: 2025-08-25 14:41:49
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].

Name	cyclo(-leu-gly)
Synonyms	L-Leucylglycine diketopiperazine MORPHINE TOLERANCE PEPTIDE (3S)-3-Isobutyl-2,5-piperazinedione 2,5-Piperazinedione, 3-(2-methylpropyl)-, (3S)- MORPHIN,TOLERANCE PEPTIDE Cyclo(Leu-Gly) 3-isobutylpiperazine-2,5-quinone (3S)-3-Isobutylpiperazine-2,5-dione

Description	Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine Receptor
In Vivo	Cyclo(glycyl-L-leucyl) (8 mg/kg; 皮下给药) 在阿扑吗啡 (APO) 后 24 小时给予，可减弱由急性高剂量 APO (5 mg/kg; 皮下给药) 引起的 DA 受体超敏反应[1]。 Animal Model: Male Swiss-Webster mice, 20-25g[1] Dosage: 8 mg/kg Administration: SC; single dose given 24h after apomorphine (APO) Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).
References	[1]. J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity--inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11. [2]. H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23.