| Description |
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].
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| Related Catalog |
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| Target |
GHB receptor[1]
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| In Vitro |
UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1]. UMB68 showes no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].
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| In Vivo |
UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1]. Animal Model: Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1] Dosage: 320, 660, 1000, 1778 mg/kg Administration: I.p. injection Result: Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
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| References |
[1]. Wu H, et, al. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. J Pharmacol Exp Ther. 2003 May;305(2):675-9.
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