2109805-83-4

2109805-83-4 structure

Name: UMB-136
Chemical Name: N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine
CAS Number: 2109805-83-4
Molecular Formula: C₂₄H₂₇N₅O₂
Molecular Weight: 417.504
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2020-01-11 19:11:44
Modify Date: 2024-09-24 14:48:41
A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation; dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association; enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.

Name	N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine
Synonyms	N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine Imidazo[1,2-a]pyrazin-3-amine, N-cyclohexyl-2-[4-(3,5-dimethyl-4-isoxazolyl)-2-methoxyphenyl]-

Description	A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation; dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association; enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.
References	References 1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035. View Related Products by Target Bromodomain