1635437-39-6
1635437-39-6 structure
- Name: UMB-32
- Chemical Name: N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine
- CAS Number: 1635437-39-6
- Molecular Formula: C21H23N5O
- Molecular Weight: 361.440
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-12 07:48:44
- Modify Date: 2024-02-28 19:12:01
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A novel a potent, selective inhibitor of BRD4 with Kd of 550 nM, cellular IC50 of 724 nM; also potently binds to the TAF1 (560 nM) and TAF1L (1.3 uM) bromodomains; significantly induces HIV-1 reactivation.
| Name | N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine |
|---|---|
| Synonyms |
Imidazo[1,2-a]pyrazin-3-amine, N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-
2-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)phenyl]-N-(2-methyl-2-propanyl)imidazo[1,2-a]pyrazin-3-amine N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine |
| Description | A novel a potent, selective inhibitor of BRD4 with Kd of 550 nM, cellular IC50 of 724 nM; also potently binds to the TAF1 (560 nM) and TAF1L (1.3 uM) bromodomains; significantly induces HIV-1 reactivation. |
|---|---|
| References | References 1. McKeown MR, et al. J Med Chem. 2014 Nov 13;57(21):9019-27. 2. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035. View Related Products by Target Bromodomain |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H23N5O |
| Molecular Weight | 361.440 |
| Exact Mass | 361.190247 |
| LogP | 3.48 |
| Index of Refraction | 1.644 |